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US 7,442,764 B2Granted
Reversible modification of amine-containing compounds
AssigneeMirns Bio Corporation
InventorsDavid B. Rozema, Darren Wakefield, Jon A. Wolff, Kirk Ekena, James E. Hagstrom
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Abstract
An process for the reversible modification of an amine-containing compound is described. Modification of the compound can be used to facilitate delivery of molecules to cells in vitro and in vivo or to alter interactions or activities the compounds. The described modifiers can also be utilized as cross-linkers.
Claims20
A process for reversibly modifying an amine-containing polycation polymer comprising:
- covalently attaching a disubstituted maleic anhydride containing a ligand for a cell surface receptor to an amine on the polycation polymer.
A process for reversibly modifying an amine-containing compound comprising:
- covalently attaching a disubstituted maleic anhydride containing a hydrophilic steric stabilizer to an amine on the compound.
A process for reversibly modifying an amine-containing compound comprising:
- covalently attaching a disubstituted maleic anhydride containing a ligand for a cell surface receptor to an amine on the compound.
Dependencies are inferred from the claim text.