Substituted 2-aminoimidazoles, process for their preparation, their use as medicament or diagnostic aid
AssigneeSanofi-Aventis Deutschland GmbH
InventorsUwe Heinelt, Hans-Jochen Lang, Armin Hofmeister, Klaus Wirth, Hans-Willi Jansen
Life of this patent
Estimating the term…
Abstract
Novel substituted 2-aminoimidazoles of formula I, process for their preparation, their use as medicament or diagnostic aid, and medicament containing them. The compounds of this type are useful in the prevention or treatment of various disorders and can be employed inter alia for renal disorders such as acute or chronic renal failure, for disorders of biliary function, for respiratory disorders such as snoring or sleep apneas or for stroke
Claims11
A compound of formula I, or a pharmaceutically acceptable salt or trifluoroacetic acid salt of said compound:
- where:
- R1 and R2 together with the two carbon atoms to which they are bonded, form a five-, six-, seven- or eight-membered carbon ring comprising one or two double bonds, said ring being substituted by 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 or 12 fluorine atoms and further substituted by 0, 1, or 2 radicals selected from the group consisting of OH, NR9R10, alkyl with 1, 2, 3 or 4 carbon atoms, CN, CF3 and alkoxy with 1, 2, 3 or 4 carbon atoms, wherein R9 and R10 are independently H or alkyl with 1, 2, 3 or 4 carbon atoms;
- or,
- R3, R4, R5, R6 and R7 are independently selected from the group consisting of hydrogen, F, Cl, Br, I, alkyl with 1, 2, 3 or 4 carbon atoms and substituted by 0, 1, 2, 3, 4, 5, 6, 7, 8 or 9 fluorine atoms, and alkoxy with 1, 2, 3 or 4 carbon atoms and substituted by 0, 1, 2, 3, 4, 5, 6, 7, 8 or 9 fluorine atoms, provided that R3 and R7 are not both simultaneously hydrogen;
- R8 is selected from the group consisting of H, alkyl with 1, 2, 3 or 4 carbon atoms and substituted by 0, 1, 2, 3, 4, 5, 6, 7, 8 or 9 fluorine atoms, and cycloalkyl with 3, 4 or 5 carbon atoms and substituted by 0, 1, 2, 3, 4, 5, 6, 7, 8 or 9 fluorine atoms.
Dependencies are inferred from the claim text.