Amlodipine gentisate and a method of its preparation
AssigneeSK Chemicals Co., Ltd.
InventorsJae-Sun Kim, Jin Young Choi, Je Ho Ryu, Nam Kyu Lee, Jeong-soo Jang, Woo Jae Jang, Key An Um, Do Seung Kum
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Abstract
The present invention relates to an acid salt of amlodipine gentisate and a method of its preparation. More particularly, the present invention relates to a crystalline acid salt of amlodipine gentisate of the following formula 1 prepared by reacting amlodipine and gentisic acid, which is useful for the treatment of cardiovascular diseases and has the advantages of low toxicity, excellent stability, improved pharmaceutical efficacies and long-lasting concentration in blood.
Claims5
An (S)-(−)-amlodipine gentisate of the following formula 1
A composition comprising the the amlodipine gentisate of the formula 1 in a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.