Substituted phenyl methanones

A pharmaceutical composition comprising a compound of formula IA-4

• wherein
• R1 is aryl, a cyclic amine selected from the group consisting of pyrrol-1-yl, piperidin-1-yl, piperazin-1-yl, morpholin-4-yl, thiomorpholin-4-yl, 1-oxo-thiomorpholin-4-yl and 1,1-dioxo-thiomorpholin-4-yl, OR11, SR11 or N(R12)2;
• R11 is lower alkyl, lower alkyl substituted by halogen, or —(CH2)n-cycloalkyl;
• each R12 is independently hydrogen or lower alkyl;
• R2 is NO2, CN or S(O)2-lower alkyl;
• R3 is hydrogen, halogen, lower alkyl, lower alkyl substituted by halogen, or lower alkoxy;
• R4 is hydrogen, halogen, lower alkyl, lower alkyl substituted by halogen, non cyclic amine, lower alkoxy, or benzyloxy optionally substituted by halogen;
• R5 and R6 are each independently hydrogen, halogen, lower alkyl, lower alkoxy, aryl or form together the keto group ═O;
• R′ is hydrogen, halogen, lower alkyl, lower alkoxy, or benzyloxy optionally substituted by halogen;
• R″ is hydrogen, alkyl substituted by halogen, halogen, nitro, lower alkoxy, cyano, COO-lower alkyl, benzyloxy optionally substituted by halogen, or S(O)2-cyclic amine;
• wherein the cyclic amine is selected from the group consisting of pyrrol-1-yl, piperidin-1-yl, piperazin-1-yl, morpholin-4-yl, thiomorpholin-4-yl, 1-oxo-thiomorpholin-4-yl and 1,1-dioxo-thiomorpholin-4-yl;
• or
• R3 and R″ or R4 and R′ or R″ and R4 are together with the carbon atom to which they are attached —O—(CH2)n—O— or —O—(CH2)m— or —(CH2)m—O—, or
• n is 1 or 2;
• and
• m is 2 or 3;
• or a pharmaceutically acceptable acid addition salt thereof and a pharmaceutically acceptable carrier.