Prostaglandin agonists

A compound of Formula I

• or a pharmaceutically acceptable salt thereof, wherein
• A is SO2;
• G is Ar;
• B is N;
• Q is
• —(C2-C6)alkylene-W—(C1-C3)alkylene-, said alkylenes each optionally substituted with up to four substituents independently selected from fluoro or (C1-C4)alkyl,
• —X—(C1-C5)alkylene-, said alkylene optionally substituted with up to four substituents independently selected from fluoro or (C1-C4)alkyl,
• —(C1-C5)alkylene-X—, said alkylene optionally substituted with up to four substituents independently selected from fluoro or (C1-C4)alkyl,
• —(C1-C3)alkylene-X—(C1-C3)alkylene-, said alkylenes each optionally substituted with up to four substituents independently selected from fluoro or (C1-C4)alkyl,
• —(C2-C4)alkylene-W—X—(C0-C3)alkylene-, said alkylenes each optionally substituted with up to four substituents each independently selected from fluoro or (C1-C4)alkyl,
• —(C0-C4)alkylene-X—W—(C1-C3)alkylene-, said alkylenes each optionally substituted with up to four substituents each independently selected from fluoro or (C1-C4)alkyl,
• —(C2-C5)alkylene-W—X—W—(C1-C3)alkylene-, wherein the two occurrences of W are independent of each other, said alkylenes each optionally substituted with up to four substituents each independently selected from fluoro or (C1-C4)alkyl,
• —(C1-C4)alkylene-ethenylene-(C0-C2)alkylene-X—W—(C1-C3)alkylene-, said alkylenes and said ethenylene each optionally substituted with up to four substituents each independently selected from fluoro or (C1-C4)alkyl, or
• —(C1-C4)alkylene-ethynylene-X—(C0-C3)alkylene-, said alkylenes and said ethynylene each optionally substituted with up to four substituents each independently selected from fluoro or (C1-C4)alkyl;
• Z is carboxyl, (C1-C6)alkoxycarbonyl, tetrazolyl, 1,2,4-oxadiazolyl, 5-oxo-1,2,4-oxadiazolyl, 5-oxo-1,2,4-thiadiazolyl, (C1-C4)alkylsulfonylcarbamoyl or phenylsulfonylcarbamoyl;
• K is a bond, (C1-C9)alkylene, thio(C1-C4)alkylene, (C1-C4)alkylenethio(C1-C4)alkylene, (C1-C4)alkyleneoxy(C1-C4)alkylene or oxy(C1-C4)alkylene, said (C1-C9)alkylene is optionally mono-unsaturated and wherein, when K is not a bond, K is optionally mono-, di- or tri-substituted independently with chloro, fluoro, hydroxy or methyl;
• M is —Ar3;
• Ar is pyridyl;
• said Ar is optionally substituted with up to three substituents independently selected from R3, R4 and R5 wherein R3, R4 and R5 are independently hydroxy, nitro, halo, carboxy, (C1-C7)alkoxy, (C1-C4)alkoxy(C1-C4)alkyl, (C1-C4)alkoxycarbonyl, (C1-C7)alkyl, (C2-C7)alkenyl, (C2-C7)alkynyl, (C3-C7)cycloalkyl, (C3-C7)cycloalkyl(C1-C4)alkyl, (C3-C7)cycloalkyl(C1-C4)alkanoyl, formyl, (C1-C8)alkanoyl, (C1-C6)alkanoyl(C1-C6)alkyl, (C1-C4)alkanoylamino, (C1-C4)alkoxycarbonylamino, hydroxysulfonyl, aminocarbonylamino or mono-N—, di-N,N—, di-N,N′—or tri-N,N,N′—(C1-C4)alkyl substituted aminocarbonylamino, sulfonamido, (C1-C4)alkylsulfonamido, amino, mono-N— or di-N,N—(C1-C4)alkylamino, carbamoyl, mono-N— or di-N,N—(C1-C4)alkylcarbamoyl, cyano, thiol, (C1-C6)alkylthio, (C1-C6)alkylsulfinyl, (C1-C4)alkylsulfonyl or mono-N— or di-N,N—(C1-C4)alkylaminosulfinyl;
• Ar3 is a phenyl ring;
• said Ar3 is optionally substituted with up to three substituents independently selected from R31, R41 and R51 wherein R31, R41 and R51 are independently hydroxy, nitro, halo, carboxy, (C1-C7)alkoxy, (C1-C4)alkoxy(C1-C4)alkyl, (C1-C4)alkoxycarbonyl, (C1-C7)alkyl, (C2-C7)alkenyl, (C2-C7)alkynyl, (C3-C7)cycloalkyl, (C3-C7)cycloalkyl(C1-C4)alkyl, (C3-C7)cycloalkyl(C1-C4)alkanoyl, formyl, (C1-C8)alkanoyl, (C1-C6)alkanoyl(C1-C6)alkyl, (C1-C4)alkanoylamino, (C1-C4)alkoxycarbonylamino, hydroxysulfonyl, aminocarbonylamino or mono-N—, di-N,N—, di-N,N′— or tri-N,N,N′—(C1-C4)alkyl substituted aminocarbonylamino, sulfonamido, (C1-C4)alkylsulfonamido, amino, mono-N— or di-N,N—(C1-C4)alkylamino, carbamoyl, mono-N— or di-N,N—(C1-C4)alkylcarbamoyl, cyano, thiol, (C1-C6)alkylthio, (C1-C6)alkylsulfinyl, (C1-C4)alkylsulfonyl or mono-N— or di-N,N—(C1-C4)alkylaminosulfinyl;
• W is oxy, thio, sulfino, sulfonyl, aminosulfonyl-, -mono-N—(C1-C4)alkyleneaminosulfonyl-, sulfonylamino, N—(C1-C4)alkylenesulfonylamino, carboxamido, N—(C1-C4)alkylenecarboxamido, carboxamidooxy, N—(C1-C4)alkylenecarboxamidooxy, carbamoyl, -mono-N—(C1-C4)alkylenecarbamoyl, carbamoyloxy, or -mono-N—(C1-C4) alkylenecarbamoyloxy, wherein said W alkyl groups are optionally substituted on carbon with one to three fluorines;
• X is a five or six membered aromatic ring optionally having one or two heteroatoms selected independently from oxygen, nitrogen, and sulfur;
• said ring optionally mono-, di- or tri-substituted independently with halo, (C1-C3)alkyl, trifluoromethyl, trifluoromethyloxy, difluoromethyloxy, hydroxyl, (C1-C4)alkoxy, or carbamoyl;
• and
• R3, R4, R5, R31, R41 and R51, when containing an alkyl, alkylene, alkenylene or alkynylene moiety, are optionally mono-, di- or tri-substituted on carbon independently with halo or hydroxy.