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US 7,442,683 B2Granted
Cyclic peptide
AssigneeTakara Bio Inc.
InventorsToru Kurome, Naoyuki Awazu, Kazutoh Takesako, Ikunoshin Kato
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Abstract
A novel cyclic peptide having an antifungal activity, its pharmacologically acceptable salts and antifungal medicinal compositions containing the same.
Claims3
The cyclic peptide represented by general formula (I) or a pharmacologically acceptable salt thereof:
- Wherein:
- m and n may be identical or different from each other, and are independently 0 or 1;
- X is O or NH;
- R1 is CH3(CH2)12-, CH3(H2)10CONH— or CH3(CH2)10COCH2- ;
- AA1 is L-alanine;
- AA2 is L-ornithine;
- AA3 is β-alanine, glycine, L-alanine, L-asparagine, L-aspartic acid, L- glutamic ancid, L-serine or D-allo-threonine;
- AA4 is L-serine or D-allo-threonine;
- AA5 is L-serine or D-allo-threonine;
- AA6 is D-asparagine;
- AA7 is D-allo-threonine, D-β-hydroxyvaline or D-β-hydroxyphenyl alanine;
- and
- AA8 is glycine or D-allo-threonine.
10 more elements
Dependencies are inferred from the claim text.