Method of inhibiting vascular permeability
AssigneeUniversity of Virginia Patent Foundation
InventorsMartin A. Schwartz, Rebecca A. Stockton
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Abstract
The present invention provides a method of regulating vascular permeability. A peptide inhibitor of p21-activated kinase has been found to inhibit the increase in vascular permeability induced by several factors. The present invention further provides methods of identifying regulators of vascular permeability. This peptide or other p21-activated kinase inhibitors should therefore be useful to treat disorders where vascular leak is a contributing factor.
Claims19
A method of therapeutically treating a vascular permeability associated disease or disorder in a subject in need thereof, said method comprising administering to said subject a pharmaceutical composition comprising an effective amount of at least one inhibitor of p21-activated kinase and a pharmaceutically-acceptable carrier, so as to inhibit said vascular permeability and alleviate said disease or disorder.
Dependencies are inferred from the claim text.