Nucleic acids and polypeptides which resemble Rho and which interact with cell signalling pathways and proteins
AssigneeOnyx Pharmaceuticals, Inc.
InventorsArie Abo, Ami Aronheim
Life of this patent
Estimating the term…
Abstract
The present invention relates to an isolated full-length Chp polypeptide, a biologically-active polypeptide fragment thereof, and nucleic acids which code for it. This polypeptide has various activities in regulating cell signaling and signal transduction pathways, including, e.g., a PAK regulatory domain binding activity, a PAK kinase stimulatory activity, a JNK kinase stimulatory activity, a cytoskeletal-reorganizing activity, or a Chp-specific immunogenic activity. The invention relates to all aspects of Chp, or homologs thereof, including assays for modulators, activators, ligands, etc.
Claims14
An isolated full-length Chp polypeptide, or a polypeptide fragment thereof, wherein (i) said Chp polypeptide or polypeptide fragment thereof has about 95% or greater identity to the amino acid sequence presented as SEQ ID NO:2, and (ii) said Chp polypeptide or polypeptide fragment thereof has at least one biological activity selected from the group consisting of a PAK regulatory domain binding activity, a PAK kinase stimulatory activity, a JNK kinase stimulatory activity, a cytoskeletal-reorganizing activity, a Chp-specific immunogenic activity directed to SEQ ID NO:2, and combinations thereof.
A chimeric polypeptide comprising, a full-length Chp polypeptide, or a polypeptide fragment of said full-length Chp polypeptide, wherein (i) said Chp polypeptide or Chp polypeptide fragment has about 95% or greater identity to the amino acid sequence presented as SEQ ID NO:2, and (ii) said Chp polypeptide or Chp polypeptide fragment has at least one biological activity selected from the group consisting of a PAK regulatory domain binding activity, a PAK kinase stimulatory activity, a JNK kinase stimulatory activity, a cytoskeletal-reorganizing activity, a Chp-specific immunogenic activity directed to SEQ ID NO;2, and combinations thereof.
An isolated full-length Chp polypeptide, wherein (i) said Chp polypeptide has about 95% or greater identity to the amino acid sequence presented as SEQ ID NO:2, and (ii) said Chp polypeptide has at least one biological activity selected from the group consisting of a PAK regulatory domain binding activity, a PAK kinase stimulatory activity, a JNK kinase stimulatory activity, a cytoskeletal-reorganizing activity, a Chp-specific immunogenic activity directed to SEQ ID NO:2, and combinations thereof.
Dependencies are inferred from the claim text.