Essential fungal CaYLR100w polypeptides, and methods of use
AssigneeBristol-Myers Squibb Company
InventorsYing-Kai Wang, Mengping Liu, Brian A. Dougherty, Matthew D. Healy, Daniel B. Davison, Charles E. Mazzucco, Trina Maurice
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Abstract
The present invention provides essential fungal polynucleotides and their encoded polypeptides, homologues thereof and their uses. Additionally, the invention provides methods for the identification of essential polynucleotides and fungal strains which may be used for drug screening.
Claims11
An isolated polypeptide consisting of a sequence selected from the group consisting of:
- (a) an isolated polypeptide consisting of amino acids 1 to 346 of SEQ ID NO:12;
- and
- (b) an isolated polypeptide consisting of amino acids 2 to 346 of SEQ ID NO:
- 12;
- wherein said polypeptide has keto-steroid reductase activity.
An isolated polypeptide encoded by a polynucleotide consisting of nucleotides 1 to 1038 of SEQ ID NO:1.
An isolated polypeptide encoded by a polynucleotide consisting of nucleotides 4 to 1038 of SEQ ID NO:1.
An isolated polypeptide consisting of an amino acid that is at least 95.0% identical to amino acids 1 to 346 of SEQ ID NO:12, wherein percent identity is calculated using a CLUSTALW global sequence alignment using default parameters, and wherein said polypeptide has keto-steroid reductase activity.
An isolated polypeptide consisting of at least 318 contiguous amino acids of SEQ ID NO:
- 12, wherein said polypeptide has keto-steroid reductase activity.
An isolated polypeptide consisting of amino acids 29 to 346 of SEQ ID NO:12.
An isolated polypeptide consisting of amino acids 1 to 318 of SEQ ID NO:
- 12.
Dependencies are inferred from the claim text.