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US 7,442,526 B2Granted
Method for preparing a physiologically active IL-18 polypeptide
AssigneeSmithKline Beecham Corporation
InventorsKyung O. Johanson, Robert B. Kirkpatrick, Allan R. Shatzman, Yen Sen Ho, Patrick McDevitt
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Abstract
The present invention provides a method for producing physiologically active human Interleukin-18 (“IL-18”).
Claims1
A method for producing an active human IL-18 polypeptide from a human precursor IL-18 polypeptide, comprising:
- (i) co-expressing bicistronically caspase 4, having the amino acid sequence of SEQ ID NO:4, with the human precursor IL-18 polypeptide;
- and
- (ii) purifying the active IL-18 polypeptide.
Dependencies are inferred from the claim text.