Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors

A method of identifying an agent that binds to a chemokine receptor having a first topology but does not bind to a chemokine receptor having a second topology, the method comprising,

• i. providing a first cell comprising the chemokine receptor having the first topology and a second cell comprising the chemokine receptor having the second topology, wherein the chemokine receptor is selected from the group consisting of CCR1, CCR2, CCR3, CCR4, CCR6, CCR7, CCR8, CCR9, CCR10, CXCR1, CXCR2, CXCR3, CXCR5, CXCR6, CX3CR1, CXR1, CCXCKR (CCR11), US28, ECRF3, Kaposi's Sarcoma-associated Herpesvirus GPCR, Poxvirus membrane-bound G Protein-coupled receptors, D6, and DARC.
• ii. contacting an agent to the chemokine receptor;
• and
• iii. selecting an agent that binds to the chemokine receptor having the first topology, but does not bind to the chemokine receptor having the second topology, wherein the chemokine receptor having the first topology and the chemokine receptor having the second topology have the same amino acid sequence.