Detecting mutations in the feline cardiac myosin binding protein C gene associated with hypertrophic cardiomyopathy in cats
AssigneesThe Ohio State University Research Foundation, University of California Davis
InventorsKathryn Meurs, Mark Kittleson
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Abstract
The invention pertains to methods for detecting the presence or absence of a mutation associated with hypertrophic cardiomyopathy in cats, particularly domesticated cats, and more particularly Maine Coon cats. The methods include detecting the presence or absence of a mutation in the feline MYBPC gene, and identifying feline subjects that have or are at risk of developing hypertrophic cardiomyopathy.
Claims9
A method for diagnosing feline hypertrophic cardiomyopathy or predicting the likelihood that a feline of the breed Maine Coon cat will develop hypertrophic cardiomyopathy comprising:
- a) obtaining a nucleic acid sample from the feline of the breed Maine Coon cat to be assessed;
- b) detecting in the nucleic acid sample a polynucleotide that encodes MYBPC and has a sequence as set forth in SEQ ID NO:
- 3, and determining whether the MYBPC polynucleotide has a cytosine at position 66 of SEQ ID NO:
- 3,
- wherein the presence of a cytosine at position 66 in SEQ ID NO:
- 3 indicates that the feline has feline hypertrophic cardiomyopathy or has a greater likelihood of developing feline hypertrophic cardiomyopathy than a feline having a guanine at position 66 in SEQ ID NO:
- 3.
Dependencies are inferred from the claim text.