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AssigneeAstellas Pharma Inc.
InventorsAkio Sugihara, Kazuhiro Sako, Toyohiro Sawada
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The present invention pertains to a sized product, which contains a drug, polyethylene oxide with a molecular weight of 2,000,000 or higher, and a specific size controlling agent for polyethylene oxide (substance with the appropriate plasticity and binding force) and wherein at least the above-mentioned specific size controlling agent is uniformly dispersed in the above-mentioned polyethylene oxide, a controlled-release pharmaceutical composition containing this sized product, and a method of manufacturing a controlled-release pharmaceutical composition containing this sized product. A controlled-release pharmaceutical composition with good uniformity of content can be presented by using powder particles of polyethtylene oxide with powder properties suitable for tableting, which is obtained by uniform dispersion of the specific size controlling agent for polyethylene oxide of the present invention.
A pharmaceutical composition for controlled release comprising a sized product, which comprises
A polyethylene oxide-containing sized product for controlled release pharmaceutical compositions, which contains polyethylene oxide (b) with a viscosity-average molecular weight of 2,000,000 or more and a size controlling agent uniformly dispersed in said polyethylene oxide, wherein said size controlling agent is one or two or more selected from the group consisting of polyethylene glycol that is solid at ordinary temperature, hydroxypropylmethyl cellulose of 2 to 15 mPa·s (2% w/v), hydroxypropyl cellulose of 2 to 10 mPa·s (2% w/v), and methyl cellulose of 2 to 15 mPa·s (2% w/v), sprayed as an aqueous solution;
A pharmaceutical composition for controlled release comprising a sized product, which comprises
A pharmaceutical composition for controlled release comprising a sized product, which comprises
Dependencies are inferred from the claim text.