Chemoembolisation
AssigneeBiocompatibles UK Limited
InventorsAndrew Lennard Lewis, Peter William Stratford, Simon Leppard, Pedro Garcia, Brenda Hall, Maria Victoria Fajardo Gonzalez
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Abstract
A composition for chemoembolotherapy of solid tumours comprises particles of a water-insoluble water-swellable synthetic anionic polymer and, absorbed therein an anthracycline. Suitably the polymer is a poly(vinyl alcohol) based polymer and the drug is doxorubicin.
Claims19
A composition comprising particles having a matrix of water-swellable water-insoluble polymer and, absorbed in the matrix, a water-soluble therapeutic agent, and is characterised in that the polymer has an overall anionic charge at a pH in the range 6 to 8, in that the particles, when swollen to equilibrium in water have particle sizes in the range 40-1500 μm and in that the therapeutic agent is an anthracycline compound having at least one amine group,
- wherein the level of anion in the polymer matrix is in the range 0.1 to 10 meq/g,
- wherein the polymer is covalently cross-linked and comprises cross-linked poly(vinyl alcohol);
- and
- wherein the particles are microspheres.
Dependencies are inferred from the claim text.