Antibodies against protective antigen and methods of use for passive immunization and treatment of anthrax

A pharmaceutical formulation, comprising:

• a purified antibody or fragment thereof,
• wherein said antibody or fragment thereof binds to the protective antigen (PA) portion of an anthrax toxin,
• wherein said antibody or fragment thereof comprises a heavy chain and a light chain,
• wherein said heavy chain comprises the amino acids of SEQ ID 2,
• wherein said light chain comprises the amino acids of SEQ ID 4, and
• a buffer.

A purified antibody or fragment thereof comprising a heavy chain and a light chain,

• wherein said heavy chain comprises the amino acids of SEQ ID 2, and
• wherein said light chain comprises the amino acids of SEQ ID 4;
• and
• wherein said purified antibody or fragment thereof binds to a protective antigen (PA) portion of an anthrax toxin.

A fully human monoclonal antibody or fragment thereof, wherein said antibody or fragment thereof comprises:

• a heavy chain and a light chain,
• wherein said heavy chain comprises a heavy chain CDR (complementary determining region) 1, heavy chain CDR 2, and heavy chain CDR 3 as set forth in amino acids 31-35 of SEQ ID 2, amino acids 50-66 of SEQ ID 2, and amino acids 99-110 of SEQ ID 2 respectively, and
• wherein said light chain comprises a light chain CDR 1, light chain CDR 2, and light chain CDR 3 as set forth in amino acids 24-34 of SEQ ID 4, amino acids 50-56 of SEQ ID 4, and amino acids 89-96 of SEQ ID 4 respectively;
• and
• wherein said fully human monoclonal antibody or fragment thereof binds to a protective antigen (PA) portion of an anthrax toxin.

A purified fully human antibody or fragment thereof comprising:

• a heavy chain and a light chain,
• wherein said heavy chain comprises the amino acids of SEQ ID 6, and
• wherein said light chain comprises the amino acids of SEQ ID 8;
• and
• wherein said fully human antibody or fragment thereof binds to a protective antigen (PA) portion of an anthrax toxin.

A purified fully human antibody or fragment thereof comprising:

• a heavy chain and a light chain,
• wherein said heavy chain comprises the amino acids of SEQ ID 10, and
• wherein said light chain comprises the amino acids of SEQ ID 12;
• and
• wherein said fully human antibody or fragment thereof binds to a protective antigen (PA) portion of an anthrax toxin.

A purified fully human antibody or fragment thereof comprising:

• a heavy chain and a light chain,
• wherein said heavy chain comprises the amino acids of SEQ ID 14, and
• wherein said light chain comprises the amino acids of SEQ ID 16;
• and
• wherein said fully human antibody or fragment thereof binds to a protective antigen (PA) portion of an anthrax toxin.