Compositions of minoxidil
AssigneeMcNeil Corporation
InventorsLorraine Elisabeth Pena, Maw-Sheng Wu
Life of this patent
Estimating the term…
Abstract
Novel compositions comprising minoxidil, a thickening agent, and a pharmaceutically acceptable solvent are presented. Also presented is a process for making a novel gel composition comprising minoxidil, and methods for using the novel compositions for treating and preventing hair loss in a region of a patient.
Claims44
A composition in the form of a single-phase gel comprising from about 5% to about 8% minoxidil, a crosslinked copolymer of acrylic acid as a thickening agent, and a pharmaceutically acceptable solvent, wherein said minoxidil is present at a concentration which is less than its solubility limit in said composition.
A composition in the form of a single-phase gel comprising:
- from about 5% to about 8% of minoxidil;
- from about 30% to about 80% of a first solvent selected from the group consisting of propylene glycol, dipropylene glycol, hexylene glycol, 1,3-butylene glycol, PEG-200, PEG-400, and glycerol;
- from about 10% to about 50% a second solvent selected from the group consisting of ethanol, propanol and butanol;
- from about 0.01% to about 50% of a crosslinked copolymer of acrylic acid;
- from about 0% to about 3% of a neutralizing agent;
- and
- water (qs);
- wherein said minoxidil is present at a concentration which is less than its solubility limit in said composition.
A composition in the form of a single-phase gel consisting essentially of:
- from about 5% to about 8% of minoxidil;
- from about 30% to about 80% of a first solvent selected from the group consisting of propylene glycol, dipropylene glycol, hexylene glycol, 1,3-butylene glycol, PEG-200, PEG-400, and glycerol;
- from about 10% to about 50% of a second solvent selected from the group consisting of ethanol, propanol and butanol;
- from about 0.01% to about 50% of a crosslinked copolymer of acrylic acid;
- from about 0% to about 3% of a neutralizing agent;
- optionally, one or more pharmaceutically acceptable additives or ingredients selected from the group consisting of hair conditioners, panthenol, calcium pantothenate, colorants, fragrances, vitamin E, penetration modifiers, surfactants, cosmetic agents, fatty acids and fatty acid esters, herbal extracts, henna, wetting agents, sunscreens, and anti-irritants;
- and
- water (qs);
- wherein said minoxidil is present at a concentration which is less than its solubility limit in said composition.
Dependencies are inferred from the claim text.