Process for the preparation of biphosphonic derivatives
AssigneeAlembic Limited
InventorsPandurang Balwant Deshpande, Parven Kumar Luthra
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Abstract
The present invention provides a novel process for preparation of bisphosphonic acid derivatives or pharmaceutical acceptable salt thereof, by reacting carboxylic acid having structural formula (II) with phosphorous acid and a halophosphorous compound, wherein halophosphorous compound is selected from the group comprising of PCl3, PCl5, POCl3, PBr3, POBr3, and PBr5 in presence of diphenyl ether.
Claims3
A process for the preparation of bisphosphonic acid derivatives or pharmaceutical acceptable salt thereof, having structural formula (I),
- wherein M1, M2, M3, M4 represents H or a monovalent cation, and R represents group as mentioned hereinbelow:
- comprising a step of, reacting a carboxylic acid having structural formula (II)
- wherein R has the aforesaid meaning, with phosphorous acid and a halophosphorous compound, wherein halophosphorous compound is selected from the group comprising of PCl3, PCl5, POCl3, PBr3, POBr3, and PBr5 in the presence of diphenyl ether.
A process for the preparation of Alendronic acid comprising a step of, reacting 4-amino butyric acid with phosphorous acid and a halophosphorous compound, wherein halophosphorous compound is selected from the group comprising of PCl3, PCl5, POCl3, PBr3, POBr3, and PBr5 in the presence of diphenyl ether.
A process for the preparation of Alendronate sodium comprising steps of,
- a) reacting 4-amino butyric acid with phosphorous acid and a halophosphorous compound, wherein halophosphorous compound is selected from the group comprising of PCl3, PCl5, POCl3, PBr3, POBr3, and PBr5 in the presence of diphenyl ether to obtain Alendronic acid
- b) treating Alendronic acid obtained in step (a) with sodium hydroxide.
Dependencies are inferred from the claim text.