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US 7,435,871 B2Granted
Transgenic animals bearing human Igλ light chain genes
AssigneeAmgen Fremont Inc.
InventorsLarry L. Green, Vladimir Ivanov
Life of this patent
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Abstract
The invention relates to transgenic animals bearing one or more human λ light chain loci. The invention also relates to methods and compositions for making transgenic animals that have incorporated human λ light chain loci. The invention further relates to methods of using and compositions derived from the transgenic animals that have incorporated human λ light chain loci.
Claims9
A transgenic mouse whose genome comprises a substantially complete human λ light chain locus comprising V, J, and constant region genes, wherein the mouse comprises YAC yL.
A transgenic mouse whose genome comprises:
- a) a substantially inactivated endogenous heavy chain locus;
- b) a substantially inactivated endogenous κ light chain locus;
- c) a human heavy chain locus comprising V, D, J, and constant region genes;
- d) a human κ light chain locus comprising V, J, and constant region genes;
- and
- e) a substantially complete human λ light chain locus comprising V, J, and constant region genes,
- wherein the mouse comprises YAC yL.
4 more elements
Dependencies are inferred from the claim text.