Methods for diagnosis of cardiovascular disease
AssigneeThe Brigham and Women's Hospital, Inc.
InventorRichard T. Lee
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Abstract
This invention pertains to methods and compositions for the diagnosis and treatment of cardiovascular conditions. More specifically, the invention relates to isolated molecules that can be used to diagnose and/or treat cardiovascular conditions including cardiac hypertrophy, myocardial infarction, stroke, arteriosclerosis, and heart failure.
Claims16
A method of diagnosing a cardiovascular condition characterized by increased expression of a Fit-1/ST2 nucleic acid molecule or an expression product thereof, said method comprising:
- a) contacting a biological sample from a subject with an agent, wherein said agent specifically binds to said Fit-1/ST2 nucleic acid molecule or an expression product thereof;
- and
- b) measuring the amount of bound agent and determining therefrom if the expression of said Fit-1/ST2 nucleic acid molecule or of an expression product thereof is increased relative to a predetermined value, wherein the expression increased relative to a predetermined value is diagnostic of the condition.
A method for monitoring a sample of a patient having or to suspected of having cardiovascular condition. comprising:
- assaying a sample from the patient for increased expression relative to a predetermined value of
- (i) a Fit-1/ST2 nucleic acid molecule, or
- (ii) a polypeptide encoded by the nucleic acid of part (i).
Dependencies are inferred from the claim text.