Reovirus clearance of ras-mediated neoplastic cells from mixed cellular compositions
AssigneeOncolytics Biotech Inc.
InventorsDonald Morris, Bradley G. Thompson, Matthew C. Coffey
Life of this patent
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Abstract
Reovirus can be used to selectively remove ras-mediated neoplastic cells from a cellular composition. It is of particular interest to purge autographs which may contain neoplastic cells with reovirus before transplanting the autographs back into the recipient, thereby reducing the risk of introducing or reintroducing neoplastic cells into the recipient.
Claims12
A method of reducing a risk of recurrence of tumor due to transplantation of autologous hematopoietic stem cell suspected of containing ras-mediated neoplastic cells, comprising harvesting from a subject to receive the transplant a cellular composition which comprises hematopoietic stem cells, contacting the cellular composition with a reovirus under conditions which result in oncolysis of ras-mediated neoplastic cells, and introducing the reovirus-treated composition back into the subject.
Dependencies are inferred from the claim text.