Pyrazole compound and medicinal composition containing the same

A compound represented by the formula (III), a salt thereof or a hydrate thereof:

• wherein
• R1 designates a group represented by the formula —CRb═CRc—Ar wherein Rb and Rc each independently designate a hydrogen atom, halogen atom, hydroxyl group, an optionally substituted C1-6 alkyl group, an optionally substituted C2-6 alkenyl group, an optionally substituted C1-6 alkoxy group, an optionally substituted C2-6 alkenyloxy group, an optionally substituted C1-6 alkylthio group, an optionally substituted C2-6 alkenylthio group, an optionally substituted C3-8 cycloalkenyl group, an optionally substituted 4- to 14-membered non-aromatic heterocyclic group, an optionally substituted C6-14 aryl group or an optionally substituted 5- to 14-membered heteroaryl group;
• Ar designates an optionally substituted C6-14 aryl group or an optionally substituted 5- to 14-membered heteroaryl group;
• Rd and Rf each designates a hydrogen atom and Re designates a halogen atom, hydroxyl group, cyano group, nitro group, carboxyl group, an optionally substituted C1-6 alkyl group, an optionally substituted C1-6 alkoxy group, an optionally substituted C2-7 acyl group, —CO—NR2aR2b, —NR2bCO—R2a or —NR2aR2b wherein R2a and R2b each independently designate a hydrogen atom or an optionally substituted C1-6 alkyl group;
• L designates a single bond, an optionally substituted C1-6 alkylene group, an optionally substituted C2-6 alkenylene group or an optionally substituted C2-6 alkynylene group;
• X designates a single bond, or a group represented by —NR7—, —O—, —CO—, —S—, —SO—, —SO2—, —CO—NR8-Z-, —C(O)O—, —NR8—CO-Z-, —NR8—C(O)O—, —NR8—S—, —NR8—SO—, —NR8—SO2-Z-, —NR9—CO—NR10—, —NR9—CS—NR10—, —S(O)m—NR11-Z—, —C(═NR12)—NR13—, —OC(O)—, —OC(O)—NR14— or —CH2—NR8—COR7— wherein R7, R8, R9, R10, R11, R12, R13 and R14 each independently designate a hydrogen atom, halogen atom, hydroxyl group, an optionally substituted C1-6 alkyl group, an optionally substituted C2-6 alkenyl group, an optionally substituted C2-6 alkynyl group, an optionally substituted C1-6 alkoxy group, an optionally substituted C2-6 alkenyloxy group, an optionally substituted C1-6 alkylthio group, an optionally substituted C2-6 alkenylthio group, an optionally substituted C3-8 cycloalkyl group, an optionally substituted C3-8 cycloalkenyl group, an optionally substituted 4- to 14-membered non-aromatic heterocyclic group, an optionally substituted C6-14 aryl group or an optionally substituted 5- to 14-membered heteroaryl group, Z designates a single bond or an optionally substituted C1-6 alkylene group, and m designates 0, 1 or 2;
• and
• Y designates any one group selected from the group consisting of a halogen atom, nitro group, hydroxyl group, cyano group, carboxyl group or an optionally substituted C1-6 alkyl group, an optionally substituted C2-6 alkenyl group, an optionally substituted C2-6 alkynyl group, an optionally substituted C1-6 alkoxy group, an optionally substituted C3-8 cycloalkyl group, an optionally substituted C3-8 cycloalkenyl group, an optionally substituted 4- to 14-membered non-aromatic heterocyclic group, an optionally substituted C6-14 aryl group, an optionally substituted 5- to 14-membered heteroaryl group, an optionally substituted amino group and a group represented by the formula —W—R15 wherein W designates CO or SO2;
• and R15 designates an optionally substituted C1-6 alkyl group, an optionally substituted amino group, an optionally substituted C6-14 aryl group or an optionally substituted 5- to 14-membered heteroaryl group.