Modified fluorinated nucleoside analogues
AssigneePharmasset, Inc.
InventorJeremy Clark
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Abstract
The disclosed invention provides compositions and methods of treating a Flaviviridae infection, including hepatitis C virus, West Nile Virus, yellow fever virus, and a rhinovirus infection in a host, including animals, and especially humans, using a (2′R)-2′-deoxy-2′-fluoro-2′-C-methyl nucleosides, or a pharmaceutically acceptable salt or prodrug thereof.
Claims19
A (2′R)-2′-deoxy-2′-fluoro-2′-C-methyl nucleoside (β-D or β-L) or its pharmaceutically acceptable salt of the structure:
- wherein Base is a pyrimidine base represented by the following formula
- X is O;
- R1 and R7 are independently H, a monophosphate, a diphosphate, a triphosphate, a H-phosphonate, alkyl, an alkyl sulfonyl, or an arylalkyl sulfonyl;
- and
- R3 is H and R4 is NH2 or OH.
A (2′R)-2′-deoxy-2′-fluoro-2′-C-methyl nucleoside (β-D) or its pharmaceutically acceptable salt thereof of the formula:
A (2′R)-2′-deoxy-2′-fluoro-2′-C-methyl nucleoside (β-D) or its pharmaceutically acceptable salt thereof of the formula:
Dependencies are inferred from the claim text.