Vaccine for nontypeable Haemophilus influenzae infection
AssigneeThe Research Foundation of State University of New York
InventorsThomas Hiltke, Timothy F. Murphy, Sanjay Sethi
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Abstract
This invention provides a method for identifying strains of nontypeable Haemophilus influenzae that can be used as immunogenic compositions having specificity against a plurality of Haemophilus influenzae strains. The invention also provides compositions comprising whole cell bacteria or outer membrane protein P2 obtained from the strains for use as vaccines.
Claims9
An immunogenic composition comprising at least five nontypeable Haemophilus influenzae (NTHI) outer membrane protein P2 (OMP P2) proteins, wherein each of the OMP P2 proteins is derived from a different NTHI strain , wherein each of the OMP P2 proteins can elicit an immune response against at least one NTHI strain from which the OMP P2 protein in the composition was not derived.
Dependencies are inferred from the claim text.