Systems and methods for the generation of crystalline polymorphs
AssigneeThe Regents of the University of Michigan
InventorsAdam J. Matzger, Meidong Lang, Kibum Kim
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Abstract
The present invention relates to systems and methods for generating polymorphs of compounds. In particular, the present invention provides high throughput systems and methods for generating and identifying new crystalline polymorphs that find use as improved drugs, pigments, explosives, nonlinear optical crystals, solid-state reactive compounds, and other polymorphic materials.
Claims25
A method for identifying crystals by exposing a sample comprising a solution containing a compound to a plurality of different surfaces to generate and identify different crystal forms of said compound, comprising:
- a) providing:
- i) a sample comprising a solution containing a compound;
- and
- ii) a polymer library comprising two or more different polymers on a solid support, wherein each of said two or more different polymers is on a separate zone of said solid support;
- b) simultaneously contacting said two or more different polymers on said solid support of said polymer library with said solution under conditions such that said two or more different polymers are undissolved in said solution so as to facilitate crystal formation, and wherein said crystals are formed on the surface of said two or more different polymers;
- c) identifying crystals formed in the presence of said polymers;
- d) analyzing said crystals formed in the presence of said polymers.
Dependencies are inferred from the claim text.