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US 7,427,396 B2Granted
AAV vectors for gene delivery to the lung
AssigneeGenzyme Corporation
InventorsAlejandra E. Arbetman, Michael A. Lochrie
Life of this patent
Estimating the term…
Abstract
Methods of making and using recombinant AAV vectors and virions for gene delivery to the lung are described. The recombinant AAV virions are derived from caprine AAV and bovine AAV, both of which display tropism for lung tissue.
Claims4
An infectious recombinant adeno-associated virus (AAV) virion comprising:
- an AAV vector comprising a heterologous nucleic acid molecule encoding a protein, wherein the nucleic acid molecule is flanked on each end with an AAV inverted terminal repeat, wherein the AAV vector is encapsidated by a viral capsid comprising caprine VP1.
Dependencies are inferred from the claim text.