Antibody composition-producing cell
AssigneeKyowa Hakko Kogyo Co., Ltd.
InventorsYutaka Kanda, Mitsuo Satoh, Kazuyasu Nakamura, Kazuhisa Uchida, Toyohide Shinkawa, Naoko Yamane, Emi Hosaka, Kazuya Yamano, Motoo Yamasaki, Nobuo Hanai
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Abstract
The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.
Claims6
An isolated mammalian host cell which has decreased or no α1,6-fucosyltransferase activity for adding fucose to N-acetylglucosamine of a reducing terminus of N-glycoside-linked sugar chains by deleting a gene encoding α1,6-fucosyltransferase or by adding a mutation to said gene to reduce or eliminate the α1,6-fucosyltranferase activity, wherein said mammalian host cell produces an antibody molecule.
Dependencies are inferred from the claim text.