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US 7,425,322 B2Granted
Responsive biomedical composites
AssigneeYissum Research Development Company of the Hebrew University of Jerusalem
InventorsDaniel Cohn, Alejandro Sosnik
Life of this patent
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Abstract
A responsive polymeric system including a responsive polymeric component capable of undergoing a transition that results in a sharp increase in viscosity in response to a triggering effected at a predetermined body site. The system includes a solid non-ceramic reinforcing component which reinforces the polymeric component, and an aqueous-based solvent wherein the viscosity of the responsive polymeric component increases by at least about 2 times upon exposure to a predetermined trigger.
Claims28
A polymeric system, comprising:
- a polymeric component capable of undergoing a transition that results in a sharp increase in viscosity in response to a triggering effect of a temperature increase from a lower temperature to a temperature of about 37° C. and wherein said polymeric component is a block copolymer comprising polyethylene oxide (PEO) and polypropylene oxide (PPO) selected from the group consisting of a diblock, a triblock, and a segmented block copolymer comprising polyethylene oxide (PEG) and polypropylene oxide (PPO) chains connected via chain extenders;
- a solid, non-ceramic reinforcing component which reinforces the polymeric component and wherein said reinforcing component is a macro, micro or nano-sized polymer material comprising methacrylic polymers or polyesters;
- and
- a water-based solvent;
- wherein the viscosity of said polymeric component increases by at least about two times upon exposure of said polymeric system to said temperature increase.
2 more elements
Dependencies are inferred from the claim text.