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US 7,424,371 B2Granted
Nucleic acid analysis
AssigneeHelicos BioSciences Corporation
InventorLee D. Kamentsky
Life of this patent
Estimating the term…
Abstract
A sample nucleic acid sequence is compared against a database to find a matching sequence. In one embodiment, this comparison is accomplished with a table look-up approach that involves using sequences with collapsed homopolymer regions.
Claims5
A method of comparing nucleic acid sequences, wherein all of the following steps are performed on a computer, the method comprising:
- providing a nucleic acid sequence obtained from a sample and including at least one homopolymer region;
- collapsing each of the homopolymer regions to a single nucleotide to form a representative sample sequence without homopolymer regions;
- and
- comparing the representative sample sequence to at least one of a plurality of collapsed reference nucleic acid sequences without homopolymer regions to determine whether the representative sample sequence matches one of the plurality of reference nucleic acid sequences;
- and
- providing results of the comparing step to a user.
3 more elements
A method of matching nucleic acid sequences, wherein all of the following steps are performed on a computer, the method comprising:
- collapsing each homopolymer region of a patient nucleic acid sequence to a single nucleotide to form a representative sample sequence;
- and
- determining whether the representative sample sequence matches a member of a database of reference nucleic acid sequences without homopolymer regions, at least one of the reference nucleic acid sequences created by collapsing at least one homopolymer region to a single nucleotide, at least some of the reference nucleic acid sequences being indicative of a diagnosis or prognosis;
- providing results of the determining step to a user.
1 more element
Dependencies are inferred from the claim text.