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US 7,423,750 B2Granted
Configurations, systems, and methods for optical scanning with at least one first relative angular motion and at least one second angular motion or at least one linear motion
AssigneeApplera Corporation
InventorsJon A. Hoshizaki, Howard Gregg King, Johannes P. Sluis, Steven J. Boege, Mark F. Oldham
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Abstract
Methods and optical systems for scanning of a target sample, including methods and systems using a low mass scan head and methods and systems for conducting a scanned optically transduced assay where the scanning includes at least one first relative angular motion and at least one second angular motion or at least one linear motion. The present invention also relates to methods and systems for performing sample assays, and for producing and measuring optical responses and signatures.
Claims20
An optical system, comprising:
- a) a sample substrate having a surface, the surface defining a 2-dimensional sample plane;
- b) an excitation source configured to provide excitation light to the sample substrate;
- c) an optical detector configured to receive emission light from the sample substrate and generate detection data;
- d) a scan head configured at least (i) to direct the excitation light towards the sample substrate, (ii) to receive emission light from the sample substrate and direct the emission light towards the optical detector, and (iii) for scanning relative to the sample substrate;
- and
- e) actuators configured to scan the scan head relative to the sample substrate,
- wherein the actuators comprise at least one of (1) a linear actuator and a rotary actuator, and the scanning comprises a relative linear motion of the linear actuator and a relative angular motion of the rotary actuator about a rotational axis generally perpendicular to the sample plane and (2) two rotary actuators, and the scanning comprises relative angular motions of the two angular actuators about two respectively different rotational axes generally perpendicular to the sample plane.
4 more elements
Dependencies are inferred from the claim text.