Compositions and methods for inhibiting expression of anti-apoptotic genes
AssigneeAlnylam Pharmaceuticals, Inc.
InventorHans-Peter Vornlocher
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Abstract
The present invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of an anti-apoptotic gene, comprising an antisense strand having a nucleotide sequence which is less that 25 nucleotides in length and which is substantially complementary to at least a part of an apoptotic gene, such as a Bcl gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of an anti-apoptotic gene using the pharmaceutical composition; and methods for inhibiting the expression of an anti-apoptotic gene in a cell.
Claims5
An isolated double-stranded ribonucleic acid (dsRNA), wherein said dsRNA comprises a sense strand consisting of SEQ ID NO:
- 29 and an antisense strand consisting of SEQ ID NO:
- 30, wherein said dsRNA is 21 to 30 nucleotides in length.
Dependencies are inferred from the claim text.