Replikins and methods of identifying replikin-containing sequences
OwnerSamuel Bogoch, Elenore S. Bogochinventors
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Abstract
The present invention provides methods for identifying a class of peptides referred to as replikins and methods of using replikins to stimulate the immune system of a subject. The method of identifying replikin peptides is based on identifying amino acid sequences comprising 7 to about 50 amino acids that contain (1) at least one lysine residue located six to ten residues from a second lysine residue; (2) at least one histidine residue; and (3) at least 6% lysine residues.
Claims20
An isolated or synthesized viral peptide consisting of 7 to about 50 amino acids wherein said peptide is isolated or synthesized by identifying a motif consisting of:
- (1) at least one lysine residue located at a first terminus of said motif and at least one lysine residue or at least one histidine residue located at a second terminus of said motif;
- (2) a first lysine residue located six to ten residues from a second lysine residue;
- (3) at least one histidine residue;
- and
- (4) at least 6% lysine residues,
- selecting said identified motif and isolating or synthesizing said peptide comprising said identified motif wherein said identified motif is selected from the group consisting of SEQ ID NO:
- 11, SEQ ID NO:
- 12, SEQ ID NO:
- 3, SEQ ID NO:
- 7, SEQ ID NO:
- 13, SEQ ID NO:
- 14, SEQ ID NO:
- 15, SEQ ID NO:
- 16 and SEQ ID NO:
- 17.
An isolated or synthesized Replikin peptide selected from the group consisting of SEQ ID NO:
- 11, SEQ ID NO:
- 12, SEQ ID NO:
- 3, SEQ ID NO:
- 7, SEQ ID NO:
- 13, SEQ ID NO:
- 14, SEQ ID NO:
- 15, SEQ ID NO:
- 16 and SEQ ID NO:
- 17.
Dependencies are inferred from the claim text.