P. gingivalis antigenic composition
AssigneesCSL Limited, The University of Melbourne
InventorsEric Charles Reynolds, Nada Slakeski, Chao Guang Chen, Ian George Barr
Life of this patent
Estimating the term…
Abstract
The present invention provides an antigenic composition, the composition comprising at least one recombinant protein. The recombinant protein comprises at least one epitope. The epitope is reactive with an antibody which is reactive with a polypeptide having the sequence set out in SEQ. ID. NO. 3 or SEQ. ID. NO. 5. The invention also provides methods and compositions for the production of the recombinant protein. Also provided are methods for the diagnosis, treatment and prevention of P. gingivalis infection.
Claims12
An antigenic composition, the composition comprising at least one isolated and purified protein having a molecular weight of less than or equal to 44 kDa as estimated by SDS-PAGE under reducing conditions, wherein the isolated and purified protein consists of a sequence selected from the group consisting of SEQ. ID. NO. 3, residues 1-184 of SEQ. ID. NO. 3, residues 1-290 of SEQ. ID. NO. 3, residues 65-184 of SEQ. ID NO. 3, residues 65-290 of SEQ. ID. NO. 3, residues 192-290 of SEQ ID No:3, and residues 147-419 of SEQ. ID. NO. 3.
An antigenic composition, the composition comprising a chimeric or fusion protein, wherein the chimeric or fusion protein comprises a first and a second polypeptide, wherein the first polypeptide consists of a sequence selected from the group consisting of SEQ. ID. NO. 3, residues 1-184 of SEQ. ID. NO. 3, residues 1-290 of SEQ. ID. NO. 3, residues 65-184 of SEQ. ID NO. 3, residues 65-290 of SEQ. ID. NO. 3, residues 192-290 of SEQ ID No:3, and residues 147-419 of SEQ. ID. NO. 3, and the second polypeptide comprises a P. gingivalis sequence.
Dependencies are inferred from the claim text.