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US 7,417,164 B2Granted
Fluorescent dyes for use in glucose sensing
AssigneeGlumetrics, Inc.
InventorJeff T. Suri
Life of this patent
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Abstract
A novel class of compounds that includes HPTS-Cys-MA, and methods of making them are disclosed herein. The class of compounds including HPTS-Cys-MA are useful as fluorescent dyes for analyte detection.
Claims13
The compound:
- wherein:
- R2 is
- R3 is —(CH2)n—A−M+,
- wherein n is 1-4,
- wherein A− is an anionic group selected from the group consisting of SO3−,
- HPO3−, CO2− and
- and
- wherein M+ is a cationic group selected from the group consisting of H+, an alkali metal ion, Li+, Na+, K+, Rb+, Cs+, Fr+, an onium ion and NR4+, wherein R is selected from the group consisting of alkyl, alkylaryl and aromatic groups);
- R4 is
- R5 is selected from the group consisting of
- wherein n is equal to 1-10, n′ is equal to 2-4 and Y is selected from the group consisting of NH and O;
- R6 is selected from the group consisting of NHR7, OR7 and CO2H;
- and
- R7 is H or an ethylenically unsaturated group selected from the group consisting of methacryloyl, acryloyl, styryl, acrylamido and methacrylamido.
11 more elements
The compound:
- wherein:
- R3 is —(CH2)n—A−M+,
- wherein n is 1-4,
- wherein A− is an anionic group selected from the group consisting of SO3−,
- HPO3−, CO2− and
- and
- wherein M+ is a cationic group selected from the group consisting of H+, an alkali metal ion, Li+, Na+, K+, Rb+, Cs+, Fr+, an onium ion and NR4+, wherein R is selected from the group consisting of alkyl, alkylaryl and aromatic groups);
- R4 is
- R8 is selected from the group consisting of
- wherein n is equal to 1-10, n′ is equal to 2-4;
- R9 is selected from the group consisting of NHR10, OR10 and CO2H;
- and
- R10 is H or an ethylenically unsaturated group selected from the group consisting of methacryloyl, acryloyl, styryl, acrylamido and methacrylamido.
10 more elements
The compound:
Dependencies are inferred from the claim text.