Nanoscale array biomolecular bond enhancer device
AssigneeSRI International
InventorPatrick Denis Lincoln
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Abstract
The invention teaches the use of an addressable nanoscale device to create a programmable substrate useful in selectively attracting proteins, nucleating protein crystals and growing protein crystals of a size amenable to diffraction analysis. Further taught is the use of nanoscale assemblies to create charge patterns, where such charge patterns are useful in purifying, nucleating or crystallizing protein molecules. Charge extension moieties, including water, are taught. The invention provides rapid and efficient identification, purification and detection of proteins and protein-related complexes.
Claims6
A device for promoting the bonding of molecules from a medium containing unbound molecules of interest, said device comprising:
- an addressable nanoscale array, said nanoscale array being multilayer and on a flexible substrate and wherein a charge pattern is imposable on a first surface of said addressable nanoscale array, such that the charge pattern is predetermined to selectively attract molecules from said medium and whereby, as a consequence of the attraction of the charge pattern, formation of bonds among said molecules of interest is effected.
Dependencies are inferred from the claim text.