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US 7,417,022 B2Granted
Compounds and compositions for delivering active agents
AssigneeMHR Institutional Partners IIA LP
InventorsAndrea Leone-Bay, Sam J. Milstein, Donald J. Sarubbi, Harry Leipold
Life of this patent
Estimating the term…
Abstract
Modified amino acid compounds useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
Claims15
A pharmacological composition comprising:
- (A) parathyroid hormone;
- and
- (B) at least one carrier compound having the formula
- 2-HO—Ar—CONR8—R7—COOH
- wherein Ar is a substituted or unsubstituted phenyl or naphthyl;
- R7 is selected from the group consisting of C4 to C20 alkyl, C4 to C20 alkenyl, phenyl, naphthyl, (C1 to C10 alkyl) phenyl, (C1 to C10 alkenyl)phenyl, (C1 to C10 alkyl) naphthyl, (C1 to C10 alkenyl)naphthyl, phenyl (C1 to C10 alkyl), phenyl (C1 to C10 alkenyl), naphthyl (C1 to C10 alkyl), and naphthyl (C1 to C10 alkenyl);
- R8 is selected from the group consisting of hydrogen, C1 to C4 alkyl, C1 to C4 alkenyl, hydroxy, and C1 to C4 alkoxy;
- R7 is optionally substituted with C1 to C4 alkyl, C1 to C4 alkenyl, C1 to C4 alkoxy, —OH, —SH and —CO2R9 any combination thereof;
- R9 is hydrogen, C1 to C4 alkyl or C1 to C4 alkenyl;
- R7 is optionally interrupted by oxygen, nitrogen, sulfur or any combination thereof;
- with the proviso that the compounds are not substituted with an amino group in the position alpha to the acid group;
- or salts thereof.
9 more elements
Dependencies are inferred from the claim text.