PD-1-lacking mouse and use thereof
AssigneesOno Pharmaceutical Co., Ltd., Tasuku Honjo
InventorsTasuku Honjo, Hiroyuki Nishimura
Life of this patent
Estimating the term…
Abstract
The invention relates to BALB/c mice that are deficient in the programmed cell death-1 receptor (PD-1), a screening method for autoimmune disease medicine using these mice, an IgG self-reactive antibody that the mice produce, a protein that specifically reacts to the antibody and is produced in heart, and a diagnostic method for dilated cardiomyopathy using the protein. Because PD-1 deficient BALB/c mice spontaneously develop autoimmune disease, and specifically dilated cardiomyopathy, they are useful for screening for medicines against these diseases.
Claims3
A null mutant BALB/c mouse whose genome comprises null mutation on both programmed cell death-1 receptor (PD-1) alleles, wherein said mouse develops dilated cardiomyopathy.
Dependencies are inferred from the claim text.