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US 7,414,076 B2Granted
Methods and compositions for treating amyloid-related diseases
AssigneeNeurochem (International) Limited
InventorsXianqi Kong, David Migneault, Isabelle Valade, Xinfu Wu, Francine Gervais
Life of this patent
Estimating the term…
Abstract
Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-related disease.
Claims32
A compound of Formula I:
- wherein:
- R1 is a substituted or unsubstituted bicyclo [2.1.2] heptyl or substituted or unsubstituted adamantyl, wherein said substituted adamantyl is substituted with alkenyl, alkynyl, halogeno, hydroxyl, alkylcarbonyloxy, arylcarbonyloxy, alkoxycarbonyloxy, aryloxy, aryloxycarbonyloxy, carboxylate, alkylcarbonyl, arylcarbonyl, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, alkylthiocarbonyl, alkoxyl, phosphate, phosphonato, phosphinato, cyano, amino, acylamino, imino, sulfnydryl, alkylthio, arylthio, thiocarboxylate, sulfates, alkylsulfinyl, sulfonato, sulfamoyl, sulfonamido, nitro, trifluoromethyl, cyano, azido, alkylaryl, or aryl;
- R2 is hydrogen or alkyl;
- Y is SO3−X+;
- X+ is hydrogen or a cationic group;
- and
- each of L1 and L1 is independently a substituted or unsubstituted C1-C5 alkyl group or absent;
- or a pharmaceutically acceptable salt, ester or prodrug thereof.
5 more elements
A compound of Formula II:
- wherein:
- R1 is a substituted or unsubstituted bicyclo [2.1.2] heptyl or substituted or unsubstituted adamantyl, wherein said substituted adamantyl is substituted with alkenyl, alkynyl, halogeno, hydroxyl, alkylcarbonyloxy arylcarbonyloxy, alkoxycarbonyloxy, aryloxy, aryloxycarbonyloxy, carboxylate, alkylcarbonyl, arylcarbonyl, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, alkylthiocarbonyl, alkoxyl, phosphate, phosphonato, phosphinato, cyano, amino, acylamino, imino, sulfhydryl, alkylthio, arylthio, thiocarboxylate, sulfates, alkylsulfinyl, sulfonato, sulfamoyl, sulfonamido, nitro, trifluoromethyl, cyano, azido, alkylaryl, or aryl,
- R2 is hydrogen, alkyl, mercaptoalkyl, alkenyl, alkynyl, cycloalkyl, aryl, or arylalkyl;
- Y is SO3−X+;
- X+ is hydrogen, a cationic group, or an ester forming moiety;
- m is 0;
- n is 1, 2, 3, or 4;
- L is substituted or unsubstituted C1-C3 alkyl group or absent;
- or a pharmaceutically acceptable salt, ester or prodrug thereof.
6 more elements
A compound of Formula II:
- wherein:
- R1 is a substituted or unsubstituted adamantyl group,
- R2 is alkyl, mercaptoalkyl, alkenyl, alkynyl, cycloalkyl, aryl, or arylalkyl;
- Y is OSO3−X+ or SSO3−X+;
- X+ is hydrogen, a cationic group, or an ester forming moiety;
- m is 0;
- n is 1, 2, 3, or 4;
- L is substituted or unsubstituted C1-C3 alkyl group or absent;
- or a pharmaceutically acceptable salt, aster or prodrug thereof.
6 more elements
A compound of Formula II:
- wherein:
- R1 is a substituted or unsubstituted bicyclo[2.1.2] heptyl or substituted or unsubstituted adamantyl group,
- R2is alkyl, mercaptoalkyl, alkenyl, alkynyl, cycloalkyl, aryl, or arylalkyl;
- Y is SO3−X+;
- X+ is hydrogen, a cationic group, or an ester forming moiety;
- m is 0;
- n is 1, 2, or 4;
- L is substituted or unsubstituted C1-C3 alkyl group or absent;
- or a pharmaceutically acceptable salt, ester or prodrug thereof.
6 more elements
Dependencies are inferred from the claim text.