Tryptophanyl-tRNA synthetase-derived polypeptides useful for the regulation of angiogenesis
AssigneeThe Scripps Research Institute
InventorsPaul Schimmel, Keisuke Wakasugi, Martin Friedlander
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Abstract
The invention provides an isolated nucleic acid encoding a water-soluble polypeptide fragment of human tryptophanyl-tRNA synthetase, which is useful for the inhibition of angiogenesis. The nucleic acid comprises a polynucleotide of SEQ ID NO: 6, a polynucleotide hybridizable to SEQ ID NO: 6, a polynucleotide that encodes the polypeptide of SEQ ID NO: 7, a polynucleotide that encodes a polypeptide of SEQ ID NO: 12, a polynucleotide that encodes a polypeptide epitope of SEQ ID NO: 7, or a polynucleotide that is hybridizable to a polynucleotide that encodes a polypeptide epitope of SEQ ID NO: 7. Vectors and recombinant cells comprising the nucleic acid are also provided.
Claims20
An isolated nucleic acid encoding a tryptophanyl-t tRNA synthetase consisting of a nucleotide sequence encoding a water-soluble polypeptide fragment of human tryptophanyl-tRNA synthetase, the region of the nucleotide sequence encoding said fragment consisting of a nucleotide sequence that is at least 95 percent identical to the sequence of a polynucleotide selected from the group consisting of a polynucleotide of SEQ ID NO:
- 6, a polynucleotide that encodes the polypeptide consisting of SEQ ID NO:
- 7 and a polynucleotide that encodes a polypeptide consisting of SEQ ID NO:
- 12.
Dependencies are inferred from the claim text.