Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds
AssigneesEidgenossische Technische Hochschule Zurich, UniversitäT ZüRich
InventorsJeffrey A. Hubbell, Donald Elbert, Ronald Schoenmakers
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Abstract
The invention features polymeric biomaterials formed by nucleophilic addition reactions to conjugated unsaturated groups. These biomaterials may be used for medical treatments.
Claims42
A biomaterial formed by combining two or more precursor components under conditions that allow polymerization of the two components, wherein said polymerization occurs through self selective reaction between a strong nucleophile and a conjugated unsaturated bond or a conjugated unsaturated group, by nucleophilic addition, wherein each of said precursor components comprises at least two strong nucleophiles or at least two conjugated unsaturated bonds or conjugated unsaturated groups, said biomaterial does not comprise unprocessed albumin, and said unsaturated bond or group is not a maleimide or a vinyl sulfone.
A biomaterial formed by combining two or more precursor components under conditions that allow polymerization of the two components, wherein said polymerization occurs through self selective reaction between an amine and a conjugated unsaturated bond or a conjugated unsaturated group, by nucleophulic addition, wherein each of said precursor components comprises at least two amines or at least two conjugated unsaturated bonds or conjugated unsaturated groups, said biomaterial does not comprise unprocessed albumin, and said unsaturated bond or group is not a maleimide or a vinyl sulfone.
A kit comprising:
- (i) a precursor component comprising at least two strong nucleophiles;
- and
- (ii) a precursor component comprising at least two conjugated unsaturated bonds or conjugated unsaturated groups,
- wherein said precursor components are capable of polymerizing to form a biomaterial through self selective reaction between a strong nucleophile and a conjugated unsaturated bond or a conjugated unsaturated group, by nucleophilic addition, wherein said precursor components do not comprise unprocessed albumin, and said unsaturated bond or group is not a maleimide or a vinyl sulfone.
Dependencies are inferred from the claim text.