# US 7,412,285 B2 · Method and device for treating cancer with electrical therapy in conjunction with chemotherapeutic agents and radiation therapy

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- Number: US 7,412,285 B2
- Document ID: US7412285B2
- Status: Granted
- Kind: B2
- Application number: 10/434,400
- Filed: 2003-05-07
- Published: 2004-01-15
- Granted: 2008-08-12
- Earliest claimed: 1999-04-09
- Assignees: OncoStim. Inc.
- Inventors: Edward A. Schroeppel; Mark W. Kroll; Kai Kroll
- Web page: https://patentgrep.com/patent/US7412285B2

## CPC

- A61N 1/326: {for promoting growth of cells, e.g. bone cells}
- A61K 47/6957: {the form being a device or a kit, e.g. stents or microdevices}
- A61N 1/205: {for promoting a biological process}
- A61N 1/30: Apparatus for iontophoresis, {i.e. transfer of media in ionic state by an electromotoric force into the body}, or cataphoresis
- A61N 1/36002: {Cancer treatment, e.g. tumour}
- A61N 5/1001: {using radiation sources introduced into or applied onto the body; brachytherapy}
- A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

This invention relates generally to the electrical treatment of malignant tumors and neoplasms by applying a voltage to affected tissue. Devices and various adaptations therein are described for use in electrical therapy. Additionally, various chemotherapeutic agent and radiation therapies are described which may be advantageously used in conjunction with electrical therapy to ameliorate cancer.

## Claims

### Claim 1

A medical device for the treatment of cancer comprising:
an implantable portion comprising:
a device housing;
circuitry contained within said device housing;
at least one electrode operably coupled to said circuitry wherein said circuitry delivers electrical therapy to said at least one electrode for the treatment of cancerous tumors;
an external portion comprising:
a means for providing power to said implantable portion; and
a communication means for communicating between said implantable portion and said external portion;
wherein said external portion receives data from said implantable portion by way of said communication means; and
wherein said data is formatted into an oncogram.

### Claim 2 (depends on 1)

The medical device of claim 1 wherein said implantable portion further comprises a power source.

### Claim 3 (depends on 2)

The medical device of claim 2 wherein said power source is a battery.

### Claim 4 (depends on 2)

The medical device of claim 2 wherein said power source is rechargeable.

### Claim 5 (depends on 2)

The medical device of claim 2 wherein said external portion recharges said implantable power source.

### Claim 6 (depends on 1)

The medical device of claim 1 wherein said means for providing power to said implantable portion is any of the group consisting of a hardwire connection and a wireless connection.

### Claim 7

A medical device for the treatment of cancer comprising:
an implantable portion comprising:
a device housing;
a port for receiving power;
circuitry contained within said device housing wherein said circuitry is coupled to said port for receiving power; and
at least one electrode operably coupled to said circuitry wherein said circuitry delivers electrical therapy to said at least one electrode for the treatment of cancerous tumors;
an external portion comprising:
a power source; and
circuitry contained within said external portion wherein said circuitry is coupled to said power source;
a wire operably coupled to said circuitry of said external portion and said port for receiving power wherein said wire transports power from said external portion to said implantable portion; and
a communication means for communicating between said implanted portion and said external portion;
wherein said external portion receives data from said implantable portion by way of said communication means;
wherein said data is formatted into an oncogram.

### Claim 8 (depends on 7)

The medical device of claim 7 wherein said power source is a battery.

### Claim 9 (depends on 7)

The medical device of claim 7 wherein said implantable portion further comprises a power source.

### Claim 10 (depends on 9)

The medical device of claim 9 wherein said power source is a battery.

### Claim 11 (depends on 10)

The medical device of claim 10 wherein said power source is rechargeable.

### Claim 12 (depends on 9)

The medical device of claim 9 wherein said external portion recharges said power source of said implantable portion.

### Claim 13 (depends on 7)

The medical device of claim 7 wherein said implantable portion further comprises a drug port.