US 7,411,072 B2 · Tricyclic steroid hormone nuclear receptor modulators

Abstract

The present invention relates to methods of treating pathological disorders susceptible to steroid hormone nuclear receptor modulation comprising administering to a patient in need thereof an effective amount of a compound of the formula: or a pharmaceutically acceptable salt thereof. In addition, the present invention provides novel pharmaceutical compounds of Formula I, including the pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions which comprise as an active ingredient a compound of Formula I.

Claims7

Dependent claims

A compound of Formula I:

wherein,
“A” represents
“B” represents
and
represents:
X and Y together represent —CH2—CH2—, —CH2—O—, or —O—CH2—;
represents a double bond;
R4-R7 each independently represent hydrogen, hydroxy, halo, (C1-C6)alkyl, or (C1-C6)alkoxy;
and
R8 represents hydrogen or (C1-C6)alkyl;
or a pharmaceutically acceptable salt thereof.

8 more elements

Dependencies are inferred from the claim text.

Facts

Application

10/517,010Filed 13 Jun 2003 · us provisional application

Priority

26 Jun 2002

Published

US 2006/0063759 A123 Mar 2006

Granted

12 Aug 2008

Term ends

Not estimatedThe source records don’t support an estimate.

Classification129 codes

C07D 213/16
Containing only hydrogen and carbon atoms in addition to the ring nitrogen atom: containing only one pyridine ring
A61P 1/04
Drugs for disorders of the alimentary tract or the digestive system: for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of…
A61P 1/16
Drugs for disorders of the alimentary tract or the digestive system: for liver or gallbladder disorders, e.g. hepatoprotective agents,…
A61P 3/04
Drugs for disorders of the metabolism: anorexiants; Antiobesity agents

Tricyclic steroid hormone nuclear receptor modulators

Life of this patent

Tricyclic steroid hormone nuclear receptor modulators

Life of this patent

Abstract

Claims7