# US 7,410,558 B2 · Method and apparatus for determining a total concentration of a component in a mixture of components

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- Number: US 7,410,558 B2
- Document ID: US7410558B2
- Status: Granted
- Kind: B2
- Application number: 10/675,629
- Filed: 2003-09-30
- Published: 2005-03-31
- Granted: 2008-08-12
- Earliest claimed: 2003-09-30
- Assignees: PerkinElmer LAS, Inc.
- Inventors: Avinash Dalmia; Otto J. Prohaska
- Web page: https://patentgrep.com/patent/US7410558B2

## CPC

- G01N 30/64: Electrical detectors
- G01N 33/0013: {by a chemical reaction (a chemical reaction taking place or a gas being eliminated in one or more analysing channels G01N33/0024)}
- G01N 33/0044: {Sulphides, e.g. H2S}
- G01N 2030/125: {pyrolising}
- G01N 2030/645: {electrical conductivity detectors}
- Y10T 436/25375: Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
- Y10T 436/25875: Gaseous sample or with change of physical state
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)
- Y10T: TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION

## Abstract

The invention relates to a method and apparatus for determining a total concentration of a component in a sample, including a reactor for oxidizing or reducing the sample, a chromatographic column coupled to the reactor for separating the component in the sample, and an electrochemical gas sensor coupled to the chromatographic column for detecting the component. In further embodiments, a filter may be used instead of or in addition to the column. Moreover, multiple sensors may be used instead of or in addition to the column for simultaneously detecting multiple components.

## Claims

### Claim 1

An apparatus for determining a total concentration of a component in a sample, comprising:
a reactor for oxidizing or reducing the sample;
a chromatographic column coupled to said reactor for separating the component in the sample;
an electrochemical gas sensor directly coupled to said chromatographic column for detecting the component;
wherein said electrochemical gas sensor has a substrate, the substrate having a surface for depositing electrodes thereon,
an ionomer membrane in contact with said substrate surface,
the ionomer membrane having a first surface and a second surface,
an electrode in contact with said substrate surface,
an opening extending from said first surface to said second surface in a location proximate to said electrode for defining a passage; and
a three way contact between said gas, electrode, and ionomer membrane within said opening wherein gas simultaneously contacts said electrode and said ionomer membrane.

### Claim 2

A method for determining a total concentration of a component in a sample, comprising the steps of:
oxidizing or reducing the sample in a reactor;
separating the component from the sample using a separation device;
directly coupling an electrochemical gas sensor to the separation device for detecting the component;
providing a substrate having a surface for depositing electrodes thereon;
depositing an electrode on the substrate surface;
contacting an ionomer membrane with the electrode;
providing an opening in the ionomer membrane in an approximate area of the electrode;
extending the opening from a first surface of the ionomer membrane to a second surface of the ionomer membrane for defining a passage; and
placing a gas in the opening and contacting the gas simultaneously with the electrode and ionomer membrane within the opening.

### Claim 3 (depends on 2)

The method according to claim 2, further comprising the step of separating the component from the sample using a gas chromatograph column.

### Claim 4 (depends on 2)

The method according to claim 2, further comprising the step of coupling a plurality of electrochemical gas sensors to the separation device for detecting multiple components.

### Claim 5 (depends on 2)

The method according to claim 2, further comprising the steps of filtering out undesirable components and permitting desirable components to pass through.