# US 7,408,076 B2 · 2-Bromoanaline and 2-chloroaniline compounds

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- Number: US 7,408,076 B2
- Document ID: US7408076B2
- Status: Granted
- Kind: B2
- Application number: 11/468,185
- Filed: 2006-08-29
- Published: 2006-12-21
- Granted: 2008-08-05
- Earliest claimed: 2004-03-16
- Assignees: Boehringer Ingelheim International GmbH
- Inventors: Guisheng Li; Jianxiu Liu; Zhi-Hui Lu; Frank Roschangar; Chris Hugh Senanayake; Ming Shen
- Web page: https://patentgrep.com/patent/US7408076B2

## CPC

- C07C 237/38: having the nitrogen atom of the carboxamide group bound to a carbon atom of a ring other than a six-membered aromatic ring
- C07D 209/12: Radicals substituted by oxygen atoms
- C07D 401/04: directly linked by a ring-member-to-ring-member bond
- C07C 2601/04: with a four-membered ring
- C07C: ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)

## Abstract

Disclosed are 2-bromoaniline or 2-chloroaniline compounds of formula (I): wherein R, R1 and X are as defined. The compounds are useful as intermediates for preparing indole compounds.

## Claims

### Claim 1

A 2-bromoaniline or 2-chloroaniline compound of formula (I);
wherein:
X is Br or Cl,
R is H, C1-8 alkyl, aryl, —C(O)C1-6 alkyl, —C(O)-aryl, —S(O)2C1-6 alkyl or —S(O)aryl;
R1 is CO2M and M is selected from Na, K, Li, Mg, —CO2C1-6 alkyl, C1-6 alkylHNC(O)—,

### Claim 2 (depends on 1)

The compound of claim 1 wherein X is Br.

### Claim 3 (depends on 1)

The compound of claim 1 wherein X is Cl.

### Claim 4 (depends on 1)

The compound of claim 1 wherein R1 is CO2M where and M is selected from