# US 7,408,038 B2 · Secreted immunomodulatory proteins

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- Number: US 7,408,038 B2
- Document ID: US7408038B2
- Status: Granted
- Kind: B2
- Application number: 11/643,252
- Filed: 2006-12-20
- Published: 2007-04-26
- Granted: 2008-08-05
- Earliest claimed: 1998-09-30
- Assignees: Millennium Pharmaceuticals, Inc.
- Inventors: Samantha J. Busfield
- Web page: https://patentgrep.com/patent/US7408038B2

## CPC

- C07K 14/47: from mammals
- C07K 14/715: for cytokines; for lymphokines; for interferons
- Y10T 436/143333: Saccharide [e.g., DNA, etc.]
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)
- Y10T: TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION

## Abstract

The invention concerns cDNA molecules encoding TANGO 191 and TANGO 195, both of which are transmembrane proteins. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes. Accordingly, in one aspect, this invention provides isolated nucleic acid molecules encoding a polypeptide of the invention or biologically active portion thereof. The present invention also provides nucleic acid molecules which are suitable as primers or hybridization probes for the detection of nucleic acids encoding a polypeptide of the invention.

## Claims

### Claim 1

An isolated polypeptide comprising an amino acid sequence which is at least 95% identical to the amino acid sequence of SEQ ID NO:5, over the whole length of SEQ ID NO:5, wherein the polypeptide increases the maturation and/or proliferation of B cells.

### Claim 2 (depends on 1)

The polypeptide of claim 1, further comprising heterologous amino acid sequences.

### Claim 3

An isolated polypeptide selected from the group consisting of:
a) a polypeptide comprising the amino acid sequence of SEQ ID NO:5;
b) a polypeptide comprising amino acids 23-312 of SEQ ID NO:5; and
c) a polypeptide which is encoded by a nucleic acid molecule comprising the nucleotide sequence of SEQ ID NO:4 or SEQ ID NO:6.

### Claim 4 (depends on 3)

The polypeptide of claim 3, wherein the polypeptide comprises the amino acid sequence of SEQ ID NO:5.

### Claim 5 (depends on 3)

The polypeptide of claim 3, wherein the polypeptide comprises amino acids 23-312 of SEQ ID NO:5.

### Claim 6 (depends on 3)

The polypeptide of claim 3, wherein the polypeptide is encoded by a nucleic acid molecule comprising the nucleotide sequence of SEQ ID NO:4 or SEQ ID NO:6.

### Claim 7 (depends on 3)

The polypeptide of claim 3, further comprising heterologous amino acid sequences.

### Claim 8 (depends on 4)

The polypeptide of claim 4, further comprising heterologous amino acid sequences.

### Claim 9 (depends on 5)

The polypeptide of claim 5, further comprising heterologous amino acid sequences.

### Claim 10 (depends on 6)

The polypeptide of claim 6, further comprising heterologous amino acid sequences.