# US 7,408,037 B2 · Tumor antigen

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- Number: US 7,408,037 B2
- Document ID: US7408037B2
- Status: Granted
- Kind: B2
- Application number: 11/543,066
- Filed: 2006-10-05
- Published: 2007-02-08
- Granted: 2008-08-05
- Earliest claimed: 2000-07-31
- Assignees: Green Peptide Co., Ltd.
- Inventors: Kyogo Itoh
- Web page: https://patentgrep.com/patent/US7408037B2

## CPC

- C07K 14/4748: {Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE}
- A61K 40/10: characterised by the cell type used
- A61K 40/24: Antigen-presenting cells [APC]
- A61K 40/32: T-cell receptors [TCR]
- A61K 40/42: Cancer antigens
- A61P 1/00: Drugs for disorders of the alimentary tract or the digestive system
- A61P 1/18: for pancreatic disorders, e.g. pancreatic enzymes
- A61P 35/00: Antineoplastic agents
- A61P 37/04: Immunostimulants
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C07K 14/47: from mammals
- A61K 39/00: Medicinal preparations containing antigens or antibodies (materials for immunoassay G01N33/53)
- A61K 2039/53: {DNA (RNA) vaccination}
- A61K 2239/50: Colon
- A61K 2239/54: Pancreas
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Tumor antigen inducing and/or activating HLA-A2-restricted tumor-specific cytotoxic T lymphocytes that is activated by recognizing HLA-A2 and a tumor antigen peptide, and a peptide or polypeptide derived from the tumor antigen, a polynucleotide encoding the peptide or a complementary strand polynucleotide thereof, a transformant comprising a recombinant vector which comprises the polynucleotide are provided.

## Claims

### Claim 1

An isolated polypeptide consisting of the amino acid sequence of SEQ ID NO:49 or a peptide fragment thereof, wherein said fragment is selected from the group consisting of SEQ ID NO:16, SEQ ID NO:17, and SEQ ID NO:18.

### Claim 2

A composition comprising a polypeptide consisting of the amino acid sequence of SEQ ID NO:49 or a peptide fragment thereof, wherein said fragment is selected from the group consisting of SEQ ID NO:16, SEQ ID NO:17, and SEQ ID NO:18, and a pharmaceutically acceptable carrier.

### Claim 3

A method for inducing cytotoxic T lymphocytes, comprising contacting, in vitro, lymphocytes with a composition comprising peripheral blood-mononuclear cells incubated together with a peptide fragment selected from the group consisting of SEQ ID NO:16, SEQ ID NO:17 and SEQ ID NO:18, wherein the lymphocytes contain HLA-A2-restricted cytotoxic T lymphocytes.