# US 7,408,036 B2 · Human voltage gated sodium channel β1A subunit and methods of use

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- Number: US 7,408,036 B2
- Document ID: US7408036B2
- Status: Granted
- Kind: B2
- Application number: 11/370,490
- Filed: 2006-03-08
- Published: 2006-11-30
- Granted: 2008-08-05
- Earliest claimed: 2000-06-07
- Assignees: Ortho-McNeil Pharmaceutical, Inc.
- Inventors: Ning Qin; Ellen Codd; Michael D'Andrea
- Web page: https://patentgrep.com/patent/US7408036B2

## CPC

- C07K 16/2803: {against the immunoglobulin superfamily}
- A61P 9/06: Antiarrhythmics
- A61P 21/02: Muscle relaxants, e.g. for tetanus or cramps
- A61P 23/02: Local anaesthetics
- A61P 25/02: for peripheral neuropathies
- A61P 25/08: Antiepileptics; Anticonvulsants
- C07K 14/705: Receptors; Cell surface antigens; Cell surface determinants {(tumour specific antigens C07K14/4748)}
- C07K 2319/00: Fusion polypeptide
- C12N 2799/021: for the expression of a heterologous nucleic acid
- C12N 2799/026: where the vector is derived from a baculovirus
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00)

## Abstract

DNAs encoding human voltage gated sodium channel β1A subunit have been cloned and characterized. The recombinant protein is capable of forming biologically active protein. The cDNA's have been expressed in recombinant host cells that produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.

## Claims

### Claim 1

An isolated protein encoded by a nucleic acid sequence having the sequence of SEQ ID NO: 12.

### Claim 2 (depends on 1)

The protein according to claim 1, having an amino acid sequence of (SEQ.ID.NO.:14).