# US 7,407,980 B2 · Imidazolinylmethyl aralkylsulfonamides

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- Number: US 7,407,980 B2
- Document ID: US7407980B2
- Status: Granted
- Kind: B2
- Application number: 10/823,012
- Filed: 2004-04-13
- Published: 2004-10-28
- Granted: 2008-08-05
- Earliest claimed: 2002-04-23
- Assignees: Roche Palo Alto LLC
- Inventors: Michael Patrick Dillon; Clara Jeou Jen Lin; Counde O'Yang; Xiaoming Zhang
- Web page: https://patentgrep.com/patent/US7407980B2

## CPC

- C07D 233/24: Radicals substituted by nitrogen atoms not forming part of a nitro radical
- A61P 1/14: Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A61P 3/04: Anorexiants; Antiobesity agents
- A61P 11/02: Nasal agents, e.g. decongestants
- A61P 13/00: Drugs for disorders of the urinary system
- A61P 13/02: of urine or of the urinary tract, e.g. urine acidifiers
- A61P 15/00: Drugs for genital or sexual disorders (for disorders of sex hormones A61P5/24); Contraceptives
- A61P 15/08: for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A61P 25/00: Drugs for disorders of the nervous system
- A61P 25/02: for peripheral neuropathies
- A61P 25/22: Anxiolytics
- A61P 25/24: Antidepressants
- A61P 25/28: for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A61P 27/16: Otologicals
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C07D 405/06: linked by a carbon chain containing only aliphatic carbon atoms
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Compounds of the Formula: where R1-R6 are those defined herein and methods for producing the same. Also provided are pharmaceutical compositions comprising a Compound of Formula I and methods for their use as therapeutic agents.

## Claims

### Claim 1

A compound of Formula:
or a pharmaceutically acceptable salt, or a prodrug thereof, wherein:
R1 is methyl; and
R4 is: chloro.

### Claim 2

The compound N-[2-Chloro-4-(4,5-dihydro-1H-imidazol -2-ylmethyl)-phenyl]-methanesulfonamide.

### Claim 3 (depends on 1)

A method for producing the compound of claim 1, said method comprising contacting a nitrile compound of the formula:
wherein R1 and R4 are as recited in claim 1;
with ethylene diamine,
to produce the compound of claim 1.

### Claim 4 (depends on 1)

A composition comprising:
(a) a therapeutically effective amount of a compound of claim 1; and
(b) a pharmaceutically acceptable carrier.

### Claim 5 (depends on 1)

A method for relieving urinary incontinence comprising administering to a subject in need thereof an effective amount of a Compound of claim 1.

### Claim 6 (depends on 5)

The method of claim 5, wherein the urinary incontinence is stress incontinence.

### Claim 7 (depends on 5)

The method of claim 5, wherein the urinary incontinence is urge incontinence.