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US 7,407,953 B2Granted
Wound healing
AssigneePhotopharmica Limited
InventorsStanley Beames Brown, Cassandra Clare O'Grady
Life of this patent
Estimating the term…
Abstract
A phenothiazinium compound, compositions and medicaments for use in promoting wound healing and a method for promoting wound healing or cosmetic use by applying or administering a phenothiazinium compound of Formula (1) to a wound site or the skin, and optionally exposing the wound site or skin to light.
Claims3
A phenothiazinium compound of Formula (1)
- wherein:
- each R1-R6 is independently is selected from H, optionally substituted C1-6-alkyl, F, Cl, Br and I;
- A and B are independently selected from:
- Q is selected from optionally substituted C1-4-alkyl;
- Z is selected from C(Ra)2, O, S, SO2, and NRa in which Ra is selected from H and optionally substituted C1-4-alkyl;
- Y is a counteranion selected from F−, Br−, CI−, I−, NO3−, SCN−, ClO3−, ClO4−, IO3−, BF4−, HSO4−, H2PO4−, CH3SO4−, N3−, SO42−, HPO42−, PO43−, acetate, lactate, citrate, tartrate, glycolate, glycerate, glutamate, β-hydroxyglutamate, glucouronate, gluconate, malate and aspartate;
- and
- p is 1, 2 or 3,
- in which the optional substituents for any one of R1 to R6, Ra and Q are independently selected from Ph, F, Cl, Br, I, OH, OC1-4-alkyl, CN, OCOC1-4-alkyl, cyclohexyl, methyl-substituted cyclohexyl, cyclopentyl, methyl-substituted cyclopentyl, COOH, COOC1-4-alkyl, and SO3H.
6 more elements
A method for promoting wound healing comprising
- applying or administering to a wound site to be treated in an animal an effective amount of phenothiazinium compound of Formula (1);
- and
- optionally exposing the wound site to light,
- wherein:
- each R1-R6 is independently selected from H, optionally substituted C1-6-alkyl, F, Cl, Br and l;
- A and B are independently selected from:
- Q is selected from H and optionally substituted C1-4-alkyl;
- Z is selected from C(Ra)2, O, S, SO2, and NRa in which Ra is selected from H and optionally substituted C1-4-alkyl;
- R7 and R8 are independently selected from optionally substituted C3-6-alkyl delete the phrase;
- Y is a counteranion selected from R−, Br−, CI−, I−, NO3−, SCN−, CIO3−, ClO4−, IO3−, BF4−, HSO4−, H2PO4−, CH3SO4−, N3−, SO42−, HPO42−, PO43−, acetate, lactate, citrate, tartrate, glycolate, glycerate, glutamate, β-hydroxyglutamate, glucouronate, gluconate, malate and aspartate;
- and
- p is 1, 2 or 3,
- in which the optional substituents for any one of R1 to R8, Ra and Q are independently selected from Ph, F, Cl, Br, I, OH, OC1-4-alkyl, CN, OCOC1-4-alkyl, cyclohexyl, methyl-substituted cyclohexyl, cyclopentyl, methyl-substituted cyclopentyl, COOH, COOC1-4-alkyl, and SO3H.
10 more elements
Dependencies are inferred from the claim text.