# US 7,407,945 B2 · Use of sulfated glycosaminoglycans for establishing effective labor in women

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- Number: US 7,407,945 B2
- Document ID: US7407945B2
- Status: Granted
- Kind: B2
- Application number: 10/500,284
- Filed: 2003-01-02
- Published: 2005-04-07
- Granted: 2008-08-05
- Earliest claimed: 2002-01-02
- Assignees: Dilafor AB
- Inventors: Gunvor Ekman-Ordeberg; Anders Malmström
- Web page: https://patentgrep.com/patent/US7407945B2

## CPC

- A61K 31/726: Glycosaminoglycans, i.e. mucopolysaccharides (chondroitin sulfate, dermatan sulfate A61K31/737)
- A61K 31/727: Heparin; Heparan
- A61P 7/02: Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A61P 15/00: Drugs for genital or sexual disorders (for disorders of sex hormones A61P5/24); Contraceptives
- A61P 15/04: for inducing labour or abortion; Uterotonics
- A61P 15/06: Antiabortive agents; Labour repressants
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The invention refers to the use of sulfated glycosaminoglycans having an anticoagulant activity of 100 BP units/mg or less for the manufacture of a pharmaceutical preparation for prophylactic priming or curative treatment of the cervix and the myometrium for establishing effective labor in women.

## Claims

### Claim 1

A method for treating protracted term labor in women, comprising the step of:
administering to a pregnant woman an effective amount of at least one sulfated glycosanilnoglycan selected from the group consisting of heparan sulfate, depolymerised heparan sulfate, dermatan sulfate, depolymerised dermatan sulfate, low molecular weight heparin and depolymerised heparin, said sulfated glycosaminoglycan having an anticoagulant activity of 100 BP units/mg or less to prime or curatively treat the cervix and myometrium and for the treatment of slow progress of term labor.

### Claim 2 (depends on 1)

The method according to claim 1, wherein the at least one glycosaminoglycan comprises at least one glycosaminoglycan selected from the group consisting of heparan sulfate and depolymerised heparan sulfate.

### Claim 3 (depends on 1)

The method according to claim 1, wherein the at least one glycosainoglycan comprises at least one glycosaminoglycan selected from the group consisting of dermatan sulfate and depolymerised dermatan sulfate.

### Claim 4 (depends on 1)

The method according to claim 1, wherein the at least one glycosaminoglycan comprises depolymerised heparin having an average molecular weight below 10000 Da.

### Claim 5 (depends on 1, 2, 3, 4)

The method according to any one claims 1, 2, 3 or 4, wherein the at least one glycosaminoglycan has an anticoagulant activity of 30 BP units/mg or less.

### Claim 6 (depends on 1)

The method according to claim 1, wherein the at least one glycosaminoglycan is administered in combination with oxytocin.

### Claim 7 (depends on 1)

The method according to claim 1, wherein the at least one glycosaminoglycan is administered topically in a topical pharmaceutical preparation.

### Claim 8 (depends on 1)

The method according to claim 1, wherein the at least one glycosaminoglycan is administered in a parenteral pharmaceutical preparation.

### Claim 9 (depends on 4)

The method according to claim 4, wherein the at least one glycosaminoglycan comprises depolymerised heparin having a molecular weight not higher than 6,000 Da.

### Claim 10 (depends on 1)

A method according to claim 1, wherein the step of administering to a pregnant woman occurs only during term labor.

### Claim 11 (depends on 1)

A method according to claim 1, wherein the least one sulfated glycosaminoglycans is administered for a period of 1-30 days starting during the period wherein labor is defined as term labor.