# US 7,407,804 B1 · Human genes relating to respiratory diseases and obesity > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 7,407,804 B1 - Document ID: US7407804B1 - Status: Granted - Kind: B1 - Application number: 10/743,704 - Filed: 2003-12-22 - Granted: 2008-08-05 - Earliest claimed: 1999-07-30 - Assignees: Oscient Pharmaceuticals Corporation - Inventors: Tim Keith; Randall Little; Paul Van Eerdewegh; Josée Dupuis; Richard Del Mastro; Jason Simon; Kristina Allen; Sunil Pandit - Web page: https://patentgrep.com/patent/US7407804B1 ## CPC - C07K 16/18: against material from animals or humans - A61P 11/06: Antiasthmatics - C07K 14/47: from mammals - C07K 2317/24: containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered - C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS ## Abstract This invention relates to isolated nucleic acids comprising genes of human chromosome 12q23-qter and the proteins encoded by these genes. Expression vectors and host cells containing such genes or fragments thereof, as well as antibodies to the proteins encoded by these nucleic acids are also included herein. ## Claims ### Claim 1 An isolated nucleic acid molecule comprising the nucleotide sequence selected from the group consisting of: a) SEQ ID NO. 2, SEQ ID NO. 4, SEQ ID NO. 6, SEQ ID NO. 8, or SEQ ID NO. 10; b) the complement of SEQ ID NO. 2, SEQ ID NO. 4, SEQ ID NO. 6, SEQ ID NO. 8, or SEQ ID NO. 10; c) a nucleotide sequence comprising at least 500 consecutive nucleotides of SEQ ID NO.2, SEQ ID NO.4, SEQ ID NO. 6, SEQ ID NO. 8, or SEQ ID NO. 10; and d) the complement of (c). ### Claim 2 (depends on 1) The isolated nucleic acid molecule of claim 1 which is DNA. ### Claim 3 (depends on 1) The isolated nucleic acid molecule of claim 1 which is RNA. ### Claim 4 (depends on 1) An expression vector containing the nucleic acid molecule of claim 1. ### Claim 5 (depends on 4) An isolated host cell containing the vector of claim 4. ### Claim 6 (depends on 5) The isolated host cell of claim 5 which is a eukaryotic cell. ### Claim 7 (depends on 6) The isolated host cell of claim 6 which is a human cell. ### Claim 8 (depends on 5) The isolated host cell of claim 5 which is a prokaryotic cell. ### Claim 9 An isolated DNA or RNA comprising the nucleotide sequence selected form the group consisting of: a) 500 consecutive nucleotides of SEQ ID NO. 2, SEQ ID NO. 4, SEQ ID NO. 6, SEQ ID NO. 8, or SEQ ID NO. 10; or b) the complement of 500 consecutive nucleotides of SEQ ID NO. 2, SEQ ID NO. 4, SEQ ID NO. 6, SEQ ID NO. 8, or SEQ ID NO. 10. ### Claim 10 (depends on 9) An expression vector containing the DNA or RNA of claim 9. ### Claim 11 (depends on 10) An isolated host cell containing the vector of claim 10. ### Claim 12 (depends on 11) The isolated host cell of claim 11 which is a eukaryotic cell. ### Claim 13 (depends on 12) The isolated host cell of claim 12 which is a human cell. ### Claim 14 (depends on 11) The isolated host cell of claim 11 which is a prokaryotic cell. ### Claim 15 An isolated polynucleotide comprising the nucleotide sequence of SEQ ID NO. 4, wherein position 1389 has a cytosine to thymine substitution. ### Claim 16 An isolated nucleic acid fragment comprising at least 500 consecutive nucleotide bases of the nucleotide sequence SEQ ID NO. 1. ### Claim 17 (depends on 1) The isolated nucleic acid molecule of claim 1, wherein the nucleotide sequence is SEQ ID NO. 2. ### Claim 18 (depends on 1) The isolated nucleic acid molecule of claim 1, wherein the nucleotide sequence is SEQ ID NO. 4. ### Claim 19 (depends on 1) The isolated nucleic acid molecule of claim 1, wherein the nucleotide sequence is SEQ ID NO. 6. ### Claim 20 (depends on 1) The isolated nucleic acid molecule of claim 1, wherein the nucleotide sequence is SEQ ID NO. 8. ### Claim 21 (depends on 1) The isolated nucleic acid molecule of claim 1, wherein the nucleotide sequence is SEQ ID NO. 10. ### Claim 22 (depends on 1) The isolated nucleic acid molecule of claim 1, wherein the nucleotide sequence comprises at least 500 consecutive nucleotides of SEQ ID NO. 2. ### Claim 23 (depends on 1) The isolated nucleic acid molecule of claim 1, wherein the nucleotide sequence comprises at least 500 consecutive nucleotides of SEQ ID NO. 4. ### Claim 24 (depends on 1) The isolated nucleic acid molecule of claim 1, wherein the nucleotide sequence comprises at least 500 consecutive nucleotides of SEQ ID NO. 6. ### Claim 25 (depends on 1) The isolated nucleic acid molecule of claim 1, wherein the nucleotide sequence comprises at least 500 consecutive nucleotides of SEQ ID NO. 8. ### Claim 26 (depends on 1) The isolated nucleic acid molecule of claim 1, wherein the nucleotide sequence comprises at least 500 consecutive nucleotides of SEQ ID NO. 10.